| Game |
| Result | Moves |
Year |
Event/Locale | Opening |
| 26. Reshevsky vs Santasiere |
 | 1-0 | 20 |
1934 |
Syracuse | D95 Grunfeld |
| 27. Santasiere vs Dake |
| 0-1 | 42 |
1934 |
Syracuse NY | A25 English |
| 28. Denker vs Santasiere |
| 0-1 | 36 |
1934 |
Syracuse NY | A48 King's Indian |
| 29. Santasiere vs W A Ruth |
| 1-0 | 52 |
1935 |
ACF Chess Congress | A21 English |
| 30. Santasiere vs Dake |
| 0-1 | 58 |
1935 |
ACF Chess Congress | E38 Nimzo-Indian, Classical, 4...c5 |
| 31. J Belson vs Santasiere |
 | 1-0 | 41 |
1935 |
Milwaukee | A44 Old Benoni Defense |
| 32. Kashdan vs Santasiere |
| ½-½ | 40 |
1935 |
USA-36.Congress Masters | D92 Grunfeld, 5.Bf4 |
| 33. Santasiere vs R Ratke |
| 1-0 | 31 |
1935 |
ACF Chess Congress | D00 Queen's Pawn Game |
| 34. I A Horowitz vs Santasiere |
 | 1-0 | 38 |
1936 |
USA | B84 Sicilian, Scheveningen |
| 35. Dake vs Santasiere |
| 1-0 | 57 |
1936 |
Philadelphia ch-ACF | D02 Queen's Pawn Game |
| 36. Santasiere vs F Reinfeld |
 | 1-0 | 31 |
1937 |
New York | A00 Uncommon Opening |
| 37. Santasiere vs M Green |
| 1-0 | 44 |
1937 |
New York | A15 English |
| 38. G Treysman vs Santasiere |
| 1-0 | 47 |
1938 |
USA Championship | C74 Ruy Lopez, Modern Steinitz Defense |
| 39. Santasiere vs Kashdan |
| 0-1 | 35 |
1938 |
USA Championship | A06 Reti Opening |
| 40. Santasiere vs J Fliegel |
| 1-0 | 42 |
1938 |
Boston prelim | A97 Dutch, Ilyin-Genevsky |
| 41. I A Horowitz vs Santasiere |
| 0-1 | 27 |
1938 |
USA Championship | C24 Bishop's Opening |
| 42. Santasiere vs Kashdan |
| 1-0 | 127 |
1938 |
USA Ch fin-A | A07 King's Indian Attack |
| 43. J Moskowitz vs Santasiere |
| 1-0 | 55 |
1938 |
Boston final | B13 Caro-Kann, Exchange |
| 44. Santasiere vs F Reinfeld |
 | ½-½ | 24 |
1938 |
USA Championship | A03 Bird's Opening |
| 45. Santasiere vs M L Hanauer |
| ½-½ | 36 |
1938 |
USA Championship | A03 Bird's Opening |
| 46. Santasiere vs Fine |
| 1-0 | 61 |
1938 |
USA Championship | A07 King's Indian Attack |
| 47. Santasiere vs W Suesman |
| 1-0 | 52 |
1938 |
USA-ch | A27 English, Three Knights System |
| 48. Reshevsky vs Santasiere |
| 1-0 | 41 |
1938 |
New York | D83 Grunfeld, Grunfeld Gambit |
| 49. Fine vs Santasiere |
| 1-0 | 58 |
1939 |
New York ch-ACF | C86 Ruy Lopez, Worrall Attack |
| 50. O Ulvestad vs Santasiere |
| 1-0 | 72 |
1939 |
Ventnor City | B24 Sicilian, Closed |