| Game |
| Result | Moves |
Year |
Event/Locale | Opening |
| 1. Antoshin vs Karpov |
 | 1-0 | 38 |
1967 |
Rusland | E12 Queen's Indian |
| 2. Vaganian vs Karpov |
| 1-0 | 28 |
1970 |
04, Leningrad tt | E12 Queen's Indian |
| 3. Petrosian vs Karpov |
| 1-0 | 39 |
1971 |
Moscow Blitz Tt | E12 Queen's Indian |
| 4. Petrosian vs Karpov |
| 1-0 | 65 |
1973 |
USSR Championship | E14 Queen's Indian |
| 5. Korchnoi vs Karpov |
| 1-0 | 19 |
1974 |
Karpov-Korchnoi Candidates Match | E17 Queen's Indian |
| 6. Kasparov vs Karpov |
| 1-0 | 41 |
1984 |
Karpov-Kasparov World Championship Match | E12 Queen's Indian |
| 7. Larsen vs Karpov |
| 1-0 | 43 |
1987 |
Brussels 5' ;CBM 02 | E15 Queen's Indian |
| 8. Korchnoi vs Karpov |
| 1-0 | 57 |
1987 |
Brussels 5' ;CBM 02 | E18 Queen's Indian, Old Main line, 7.Nc3 |
| 9. Kasparov vs Karpov |
| 1-0 | 59 |
1987 |
Brussels | E12 Queen's Indian |
| 10. A Chernin vs Karpov |
| 1-0 | 43 |
1988 |
St John | E12 Queen's Indian |
| 11. Timman vs Karpov |
| 1-0 | 55 |
1991 |
02, Paris Immopar 25' ;EXP 26 | E15 Queen's Indian |
| 12. Zsuzsa Polgar vs Karpov |
| 1-0 | 36 |
1992 |
Roquebrune 5' ;EXP 27 | E15 Queen's Indian |
| 13. Gelfand vs Karpov |
| 1-0 | 37 |
1992 |
It (Alekhin's Memorial,cat.18) | E12 Queen's Indian |
| 14. Seirawan vs Karpov |
| 1-0 | 58 |
1992 |
01, Roquebrune 30' ;CBM 28 | E12 Queen's Indian |
| 15. Bareev vs Karpov |
| 1-0 | 34 |
1992 |
6'-5', Paris Immopar ;CBM 33 (3) | E12 Queen's Indian |
| 16. Bareev vs Karpov |
| 1-0 | 53 |
1992 |
25', Paris Immopar ;CBM 33 (1) | E12 Queen's Indian |
| 17. Christiansen vs Karpov |
| 1-0 | 12 |
1993 |
02, Wijk m ;CBM 34 | E12 Queen's Indian |
| 18. Kurajica vs Karpov |
| 1-0 | 41 |
1994 |
02, Tilburg 20' | E14 Queen's Indian |
| 19. Bareev vs Karpov |
| 1-0 | 54 |
1994 |
Netherlands, It | E14 Queen's Indian |
| 20. Piket vs Karpov |
| 1-0 | 28 |
1995 |
10, Monaco blind ;EXP 46 | E15 Queen's Indian |
| 21. Lautier vs Karpov |
| 1-0 | 34 |
1996 |
05, Amber Blindfold Monte Carlo | E12 Queen's Indian |
| 22. Van Wely vs Karpov |
| 1-0 | 66 |
1996 |
Tilburg Fontys | E15 Queen's Indian |
| 23. Bareev vs Karpov |
| 1-0 | 43 |
1996 |
cat.16, It , Belgrade (Yugoslavia) | E12 Queen's Indian |
| 24. Kamsky vs Karpov |
| 1-0 | 59 |
1996 |
Karpov-Kamsky FIDE World Championship | E12 Queen's Indian |
| 25. Kamsky vs Karpov |
| 1-0 | 49 |
1996 |
Karpov-Kamsky FIDE World Championship | E15 Queen's Indian |
