| Game |
| Result | Moves |
Year |
Event/Locale | Opening |
| 1. Karpov vs Spassky |
 | ½-½ | 41 |
1974 |
1/2, ct, Leningrad | D31 Queen's Gambit Declined |
| 2. Karpov vs B Ivanovic |
| 1-0 | 42 |
1976 |
08, Skopje | D31 Queen's Gambit Declined |
| 3. Karpov vs Kasparov |
| 1-0 | 42 |
1985 |
Karpov-Kasparov World Championship Match | D31 Queen's Gambit Declined |
| 4. Karpov vs Kasparov |
| ½-½ | 85 |
1985 |
Karpov-Kasparov World Championship Match | D31 Queen's Gambit Declined |
| 5. Karpov vs Kasparov |
| ½-½ | 43 |
1986 |
Karpov-Kasparov World Championship Rematch | D31 Queen's Gambit Declined |
| 6. Karpov vs Yusupov |
| 1-0 | 43 |
1988 |
URS-ch55 Moscow ;URS-ch | D31 Queen's Gambit Declined |
| 7. Karpov vs Portisch |
| 1-0 | 57 |
1989 |
Linares 47/485 [Karpov,An | D31 Queen's Gambit Declined |
| 8. Karpov vs Yusupov |
| 1-0 | 58 |
1989 |
Rotterdam 47/495 [Karpov,An | D31 Queen's Gambit Declined |
| 9. Karpov vs Ivanchuk |
| ½-½ | 47 |
1993 |
Tilburg | D31 Queen's Gambit Declined |
| 10. Karpov vs R Ekstroem |
| 1-0 | 35 |
1993 |
Netherlands, Cup European Club, Hilversum | D31 Queen's Gambit Declined |
| 11. Karpov vs E Raaste |
| 1-0 | 57 |
1996 |
06, Karpov v Finland sim, Helsinki FIN | D31 Queen's Gambit Declined |
| 12. Karpov vs J Long |
| ½-½ | 36 |
1997 |
Simultan, Singapore | D31 Queen's Gambit Declined |
| 13. Karpov vs W Bartelski |
| 1-0 | 40 |
2003 |
Simul | D31 Queen's Gambit Declined |
