| Game |
| Result | Moves |
Year |
Event/Locale | Opening |
| 1. Karpov vs Maksimov |
 | 1-0 | 60 |
1961 |
Magnitogorsk | E81 King's Indian, Samisch |
| 2. Karpov vs M Dvoretsky |
 | 1-0 | 46 |
1967 |
04, Moscow | E81 King's Indian, Samisch |
| 3. Karpov vs J Barle |
 | 1-0 | 24 |
1975 |
05, Portoroz/Ljubljana | E81 King's Indian, Samisch |
| 4. Karpov vs M Gallati |
 | 1-0 | 28 |
1988 |
Zurich | E81 King's Indian, Samisch |
| 5. Karpov vs Kasparov |
 | ½-½ | 30 |
1990 |
Karpov-Kasparov World Championship Match | E81 King's Indian, Samisch |
| 6. Karpov vs M Gurevich |
 | 1-0 | 78 |
1991 |
Reggio Emilia 51/594 [Karpov,An | E81 King's Indian, Samisch |
| 7. Karpov vs Judit Polgar |
 | 1-0 | 43 |
1992 |
11, Roquebrune 30' ;CBM 28 | E81 King's Indian, Samisch |
| 8. Karpov vs Ivanchuk |
 | 1-0 | 51 |
1993 |
It | E81 King's Indian, Samisch |
| 9. Karpov vs Bacrot |
 | 1-0 | 64 |
1993 |
10, Paris EURO DISNEY | E81 King's Indian, Samisch |
| 10. Karpov vs Timman |
 | 1-0 | 59 |
1993 |
Karpov-Timman FIDE World Championship | E81 King's Indian, Samisch |
| 11. Karpov vs Timman |
 | ½-½ | 38 |
1993 |
Karpov-Timman FIDE World Championship | E81 King's Indian, Samisch |
| 12. Karpov vs A Romero Holmes |
| ½-½ | 50 |
1993 |
05, Leon ;CBM 36 | E81 King's Indian, Samisch |
| 13. Karpov vs Topalov |
 | ½-½ | 72 |
1993 |
Leon 57/574 [Karpov,An | E81 King's Indian, Samisch |
| 14. Karpov vs Nunn |
 | 1-0 | 44 |
1993 |
Wijk aan Zee 56/671 [Karpov,An | E81 King's Indian, Samisch |
| 15. Karpov vs M Krysztofiak |
| 1-0 | 25 |
1997 |
Simul, Koszalin POL | E81 King's Indian, Samisch |
| 16. Karpov vs I Plotnikov |
| 1-0 | 24 |
1997 |
Simultan, Voronezh (Russia) | E81 King's Indian, Samisch |
| 17. Karpov vs Wang Pin |
 | 1-0 | 47 |
1998 |
Simultan, Beijing (China) | E81 King's Indian, Samisch |
| 18. Karpov vs G Mamalakis |
| 1-0 | 31 |
2001 |
Rethymno simul | E81 King's Indian, Samisch |
| 19. Karpov vs V Papadopoulou |
| ½-½ | 33 |
2001 |
Rethymno simul | E81 King's Indian, Samisch |
| 20. Karpov vs E Zournatsidis |
| ½-½ | 47 |
2001 |
Rethymno simul | E81 King's Indian, Samisch |