| Game |
| Result | Moves |
Year |
Event/Locale | Opening |
| 1. Karpov vs J Konikowski |
| 1-0 | 26 |
1969 |
Warszawa ch-armies | D37 Queen's Gambit Declined |
| 2. Karpov vs Spassky |
 | ½-½ | 41 |
1974 |
1/2, ct, Leningrad | D31 Queen's Gambit Declined |
| 3. Karpov vs B Ivanovic |
 | 1-0 | 42 |
1976 |
08, Skopje | D31 Queen's Gambit Declined |
| 4. Karpov vs K Wockenfuss |
 | 1-0 | 30 |
1977 |
Bad Lauterberg 23/542 | D30 Queen's Gambit Declined |
| 5. Karpov vs Spassky |
 | 1-0 | 41 |
1979 |
It, Montreal | D37 Queen's Gambit Declined |
| 6. Karpov vs T Georgadze |
| ½-½ | 24 |
1979 |
Spartakiada | D37 Queen's Gambit Declined |
| 7. Karpov vs Beliavsky |
 | 1-0 | 34 |
1981 |
4, Moscow INT | D37 Queen's Gambit Declined |
| 8. Karpov vs Beliavsky |
| 1-0 | 38 |
1981 |
Moscow | D37 Queen's Gambit Declined |
| 9. Karpov vs Kasparov |
 | ½-½ | 85 |
1985 |
Karpov-Kasparov World Championship Match | D31 Queen's Gambit Declined |
| 10. Karpov vs Kasparov |
 | 1-0 | 47 |
1985 |
Karpov-Kasparov World Championship Match | D31 Queen's Gambit Declined |
| 11. Karpov vs Kasparov |
 | ½-½ | 43 |
1986 |
Karpov-Kasparov World Championship Rematch | D31 Queen's Gambit Declined |
| 12. Karpov vs Beliavsky |
 | 0-1 | 36 |
1986 |
11, Tilburg ;CBM 03 | D35 Queen's Gambit Declined |
| 13. Karpov vs Tal |
 | 1-0 | 51 |
1987 |
Brussels 5' ;CBM 02 | D38 Queen's Gambit Declined, Ragozin Variation |
| 14. Karpov vs Ljubojevic |
 | 1-0 | 63 |
1988 |
Karpov,A, Wijk aan Zee 45/461 | D30 Queen's Gambit Declined |
| 15. Karpov vs G Kuzmin |
 | 1-0 | 46 |
1988 |
Gijon | D38 Queen's Gambit Declined, Ragozin Variation |
| 16. Karpov vs A Kharitonov |
| 1-0 | 42 |
1988 |
ch, USSR 46/536 [Karpov,An; Zaitsev,I | D35 Queen's Gambit Declined |
| 17. Karpov vs A Sokolov |
| 1-0 | 51 |
1988 |
Kovacevic,Vlado, Bruxelles 45/612 | D37 Queen's Gambit Declined |
| 18. Karpov vs Yusupov |
 | 1-0 | 43 |
1988 |
URS-ch55 Moscow ;URS-ch | D31 Queen's Gambit Declined |
| 19. Karpov vs Hjartarson |
| 1-0 | 53 |
1988 |
Belfort WCup ;CBM 08 | D37 Queen's Gambit Declined |
| 20. Karpov vs Vaganian |
 | ½-½ | 38 |
1988 |
URS-ch55 Moscow ;URS-ch | D35 Queen's Gambit Declined |
| 21. Karpov vs Beliavsky |
| 1-0 | 60 |
1988 |
Karpov,A, Belfort 45/476 | D35 Queen's Gambit Declined |
| 22. Karpov vs A Kuzmin |
 | 1-0 | 46 |
1988 |
Gijon/SW,23,19 | D38 Queen's Gambit Declined, Ragozin Variation |
| 23. Karpov vs Short |
 | 1-0 | 65 |
1989 |
Luzern 48/535 [Karpov,An | D35 Queen's Gambit Declined |
| 24. Karpov vs Ljubojevic |
 | 1-0 | 45 |
1989 |
Linares 47/501 [Karpov,An | D35 Queen's Gambit Declined |
| 25. Karpov vs Portisch |
 | 1-0 | 57 |
1989 |
Linares 47/485 [Karpov,An | D31 Queen's Gambit Declined |