| Game |
| Result | Moves |
Year |
Event/Locale | Opening |
| 1. Spassky vs J Yuchtman |
 | 1-0 | 28 |
1952 |
Rostov on Don | E28 Nimzo-Indian, Samisch Variation |
| 2. Spassky vs O'Kelly |
| ½-½ | 48 |
1953 |
Bucharest | E26 Nimzo-Indian, Samisch |
| 3. Spassky vs Golombek |
| 1-0 | 25 |
1953 |
Bucharest | E30 Nimzo-Indian, Leningrad |
| 4. Spassky vs Smyslov |
 | 1-0 | 35 |
1953 |
1, Bucharest | E31 Nimzo-Indian, Leningrad, Main line |
| 5. Spassky vs Portisch |
| 1-0 | 36 |
1955 |
Wch U20 final-A | E30 Nimzo-Indian, Leningrad |
| 6. Spassky vs Filip |
 | 1-0 | 40 |
1955 |
Gothenburg Interzonal | E30 Nimzo-Indian, Leningrad |
| 7. Spassky vs Smyslov |
 | ½-½ | 23 |
1956 |
Amsterdam | E46 Nimzo-Indian |
| 8. Spassky vs Petrosian |
| ½-½ | 33 |
1956 |
Amsterdam | E46 Nimzo-Indian |
| 9. Spassky vs Lisitsin |
 | 1-0 | 43 |
1956 |
USSR Championship | E30 Nimzo-Indian, Leningrad |
| 10. Spassky vs A Khasin |
 | ½-½ | 47 |
1957 |
USSR Championship | E54 Nimzo-Indian, 4.e3, Gligoric System |
| 11. Spassky vs Kholmov |
 | ½-½ | 41 |
1957 |
USSR Championship | E30 Nimzo-Indian, Leningrad |
| 12. Spassky vs Keres |
 | 1-0 | 46 |
1957 |
USSR Championship | E31 Nimzo-Indian, Leningrad, Main line |
| 13. Spassky vs Gurgenidze |
 | 1-0 | 29 |
1957 |
USSR Championship | E46 Nimzo-Indian |
| 14. Spassky vs E S Stoliar |
| 1-0 | 42 |
1957 |
USSR Championship | E40 Nimzo-Indian, 4.e3 |
| 15. Spassky vs G Uusi |
 | 1-0 | 35 |
1958 |
Rostov | E28 Nimzo-Indian, Samisch Variation |
| 16. Spassky vs Krogius |
 | 1-0 | 50 |
1958 |
USSR Championship | E56 Nimzo-Indian, 4.e3, Main line with 7...Nc6 |
| 17. Spassky vs Tal |
 | 0-1 | 73 |
1958 |
USSR Championship | E26 Nimzo-Indian, Samisch |
| 18. Spassky vs J Kozma |
| ½-½ | 41 |
1958 |
WchT U26 fin-A 05th | E56 Nimzo-Indian, 4.e3, Main line with 7...Nc6 |
| 19. Spassky vs Kholmov |
| ½-½ | 19 |
1959 |
USSR Championship | E55 Nimzo-Indian, 4.e3, Gligoric System, Bronstein Variation |
| 20. Spassky vs Nikitin |
 | 1-0 | 61 |
1959 |
USSR Championship | E59 Nimzo-Indian, 4.e3, Main line |
| 21. Spassky vs Szabo |
| ½-½ | 18 |
1959 |
Leningrad-Budapest | E31 Nimzo-Indian, Leningrad, Main line |
| 22. Spassky vs Sliwa |
| ½-½ | 40 |
1959 |
Riga (Latvia) | E30 Nimzo-Indian, Leningrad |
| 23. Spassky vs Polugaevsky |
 | 1-0 | 42 |
1961 |
USSR Championship 1961b | E21 Nimzo-Indian, Three Knights |
| 24. Spassky vs A Khasin |
| ½-½ | 41 |
1961 |
USSR Championship 1961b | E30 Nimzo-Indian, Leningrad |
| 25. Spassky vs Y Nikolaevsky |
 | 1-0 | 40 |
1963 |
Moscow | E24 Nimzo-Indian, Samisch |