| Game |
| Result | Moves |
Year |
Event/Locale | Opening |
| 1. Reshevsky vs Santasiere |
 | 1-0 | 20 |
1934 |
Syracuse | D95 Grunfeld |
| 2. Kashdan vs Santasiere |
| ½-½ | 40 |
1935 |
USA-36.Congress Masters | D92 Grunfeld, 5.Bf4 |
| 3. Reshevsky vs Santasiere |
| 1-0 | 41 |
1938 |
New York | D83 Grunfeld, Grunfeld Gambit |
| 4. H Burdge vs Santasiere |
| ½-½ | 20 |
1939 |
Ventnor City | D96 Grunfeld, Russian Variation |
| 5. Morris Harry vs Santasiere |
| 0-1 | 37 |
1940 |
Ventnor City | D81 Grunfeld, Russian Variation |
| 6. J Levin vs Santasiere |
| 0-1 | 40 |
1941 |
Ventnor City | D77 Neo-Grunfeld, 6.O-O |
| 7. J Levin vs Santasiere |
| 1-0 | 58 |
1944 |
Ventnor City | D74 Neo-Grunfeld, 6.cd Nxd5, 7.O-O |
| 8. E M Jackson vs Santasiere |
| 0-1 | 49 |
1944 |
Ventnor City | D95 Grunfeld |
| 9. M Stark vs Santasiere |
| ½-½ | 22 |
1945 |
Ventnor City | D81 Grunfeld, Russian Variation |
| 10. Bronstein vs Santasiere |
 | 1-0 | 57 |
1945 |
radio USA-URS | D95 Grunfeld |
| 11. W Suesman vs Santasiere |
| 0-1 | 38 |
1945 |
Ventnor City | D80 Grunfeld |
| 12. W Grossman vs Santasiere |
| 0-1 | 47 |
1946 |
Pittsburgh | D92 Grunfeld, 5.Bf4 |
| 13. A Rothman vs Santasiere |
| 0-1 | 45 |
1946 |
New York ch-USA | D82 Grunfeld, 4.Bf4 |
| 14. Denker vs Santasiere |
| ½-½ | 51 |
1946 |
New York ch-USA | D74 Neo-Grunfeld, 6.cd Nxd5, 7.O-O |
| 15. H Gordon vs Santasiere |
 | 0-1 | 40 |
1946 |
Pittsburgh USA-open | D91 Grunfeld, 5.Bg5 |
| 16. Forster vs Santasiere |
| ½-½ | 26 |
1946 |
Pittsburgh USA-open | D96 Grunfeld, Russian Variation |
| 17. Heitner vs Santasiere |
| 0-1 | 64 |
1948 |
South Fallsburg ch-USA | D82 Grunfeld, 4.Bf4 |
| 18. A Mengarini vs Santasiere |
| ½-½ | 45 |
1951 |
New York, USA Ch | D77 Neo-Grunfeld, 6.O-O |