| Game |
| Result | Moves |
Year |
Event/Locale | Opening |
| 1. Hydra vs Karjakin |
 | 1-0 | 59 |
2004 |
Man vs Machine 120'/40+60' | C65 Ruy Lopez, Berlin Defense |
| 2. E Matsuura vs Karjakin |
 | 0-1 | 45 |
2007 |
World Chess Cup | C65 Ruy Lopez, Berlin Defense |
| 3. V Gashimov vs Karjakin |
 | ½-½ | 37 |
2009 |
Azerbaijan vs the World | C65 Ruy Lopez, Berlin Defense |
| 4. G Guseinov vs Karjakin |
 | 0-1 | 36 |
2009 |
Azerbaijan vs the World | C65 Ruy Lopez, Berlin Defense |
| 5. Kosteniuk vs Karjakin |
 | 0-1 | 36 |
2009 |
World Blitz Championship | C65 Ruy Lopez, Berlin Defense |
| 6. L Dominguez vs Karjakin |
 | ½-½ | 77 |
2009 |
World Blitz Championship | C65 Ruy Lopez, Berlin Defense |
| 7. V Gashimov vs Karjakin |
| 1-0 | 46 |
2009 |
World Blitz Championship | C65 Ruy Lopez, Berlin Defense |
| 8. M Vachier-Lagrave vs Karjakin |
| ½-½ | 66 |
2010 |
World Blitz Championship | C65 Ruy Lopez, Berlin Defense |
| 9. Movsesian vs Karjakin |
| 0-1 | 61 |
2010 |
World Blitz Championship | C65 Ruy Lopez, Berlin Defense |
| 10. Svidler vs Karjakin |
| ½-½ | 22 |
2010 |
Russian Championship Superfinal | C65 Ruy Lopez, Berlin Defense |
| 11. Kamsky vs Karjakin |
 | ½-½ | 23 |
2011 |
World Chess Team Championship | C65 Ruy Lopez, Berlin Defense |
| 12. Carlsen vs Karjakin |
 | 1-0 | 58 |
2012 |
World Rapid Championship | C65 Ruy Lopez, Berlin Defense |
| 13. Carlsen vs Karjakin |
 | 1-0 | 40 |
2012 |
World Blitz Championship | C65 Ruy Lopez, Berlin Defense |
| 14. Vallejo-Pons vs Karjakin |
| ½-½ | 55 |
2012 |
Bilbao Masters | C65 Ruy Lopez, Berlin Defense |
| 15. Ivanchuk vs Karjakin |
 | 0-1 | 47 |
2012 |
SportAccord World Mind Games (Men's Rapid) | C65 Ruy Lopez, Berlin Defense |
| 16. Svidler vs Karjakin |
| ½-½ | 41 |
2013 |
Russian Team Championships | C65 Ruy Lopez, Berlin Defense |
| 17. Caruana vs Karjakin |
 | ½-½ | 60 |
2013 |
FIDE Grand Prix Zug | C65 Ruy Lopez, Berlin Defense |
| 18. Anand vs Karjakin |
 | ½-½ | 57 |
2013 |
Norway Chess Tournament | C65 Ruy Lopez, Berlin Defense |
| 19. Svidler vs Karjakin |
 | 1-0 | 57 |
2013 |
Norway Chess Tournament | C65 Ruy Lopez, Berlin Defense |