| Game |
| Result | Moves |
Year |
Event/Locale | Opening |
| 1. Karjakin vs A E Azis |
 | 1-0 | 44 |
2001 |
EYCC B14 | B19 Caro-Kann, Classical |
| 2. Karjakin vs Areshchenko |
| 0-1 | 89 |
2001 |
Nikolaev UKR | B19 Caro-Kann, Classical |
| 3. Karjakin vs B Itkis |
| 1-0 | 37 |
2001 |
Nikolaev UKR | B19 Caro-Kann, Classical |
| 4. Karjakin vs M Turov |
| ½-½ | 31 |
2002 |
Aeroflot Open | B19 Caro-Kann, Classical |
| 5. Karjakin vs A Anastasian |
| ½-½ | 26 |
2005 |
World Team Championship | B19 Caro-Kann, Classical |
| 6. Karjakin vs K Asrian |
| 1-0 | 61 |
2005 |
6th European Individual Championship | B19 Caro-Kann, Classical |
| 7. Karjakin vs Azmaiparashvili |
| ½-½ | 25 |
2005 |
XIII Dos Hermanas | B19 Caro-Kann, Classical |
| 8. Karjakin vs M Mchedlishvili |
| 1-0 | 41 |
2005 |
World Team Championship | B19 Caro-Kann, Classical |
| 9. Karjakin vs Bologan |
| 1-0 | 51 |
2006 |
10th Petr Izmailov Memorial | B17 Caro-Kann, Steinitz Variation |
| 10. Karjakin vs Nisipeanu |
| ½-½ | 20 |
2007 |
World Chess Cup | B12 Caro-Kann Defense |
| 11. Karjakin vs Khenkin |
| ½-½ | 19 |
2007 |
Ordix Open | B12 Caro-Kann Defense |
| 12. Karjakin vs Motylev |
| ½-½ | 21 |
2007 |
Corus | B12 Caro-Kann Defense |
| 13. Karjakin vs Short |
| 1-0 | 37 |
2008 |
Karjakin-Short Rapid match | B12 Caro-Kann Defense |
| 14. Karjakin vs Carlsen |
| 0-1 | 70 |
2008 |
Tal Memorial Blitz | B12 Caro-Kann Defense |
| 15. Karjakin vs K Asrian |
| ½-½ | 53 |
2008 |
Russian Team Championship | B12 Caro-Kann Defense |
| 16. Karjakin vs Ponomariov |
| 1-0 | 71 |
2008 |
Tal Memorial Blitz | B12 Caro-Kann Defense |
| 17. Karjakin vs Leko |
| ½-½ | 75 |
2008 |
Amber Tournament (Rapid) | B12 Caro-Kann Defense |
| 18. Karjakin vs I Cheparinov |
| 1-0 | 54 |
2008 |
FIDE Grand Prix | B12 Caro-Kann Defense |
| 19. Karjakin vs Topalov |
| ½-½ | 56 |
2008 |
Amber Tournament (Blindfold) | B18 Caro-Kann, Classical |
| 20. Karjakin vs Short |
| 1-0 | 59 |
2008 |
Karjakin-Short Rapid match | B12 Caro-Kann Defense |
| 21. Karjakin vs Morozevich |
| 0-1 | 46 |
2009 |
Amber Tournament (Blindfold) | B12 Caro-Kann Defense |
| 22. Karjakin vs Karpov |
| ½-½ | 43 |
2009 |
World Blitz Championship | B12 Caro-Kann Defense |
| 23. Karjakin vs Bareev |
| 1-0 | 43 |
2009 |
World Blitz Championship | B12 Caro-Kann Defense |
| 24. Karjakin vs Kamsky |
| ½-½ | 43 |
2009 |
FIDE Jermuk Grand Prix | B12 Caro-Kann Defense |
| 25. Karjakin vs Anand |
| 0-1 | 33 |
2009 |
Amber Tournament (Blindfold) | B12 Caro-Kann Defense |
