| Game |
| Result | Moves |
Year |
Event/Locale | Opening |
| 1. Caruana vs R Ziatdinov |
| 0-1 | 22 |
2003 |
World Open: Open Section | C53 Giuoco Piano |
| 2. Caruana vs M Galyas |
| 0-1 | 50 |
2005 |
FSIM June | C18 French, Winawer |
| 3. Caruana vs G Lettieri |
| 0-1 | 49 |
2005 |
FSIM June | B50 Sicilian |
| 4. Tri Hoang vs Caruana |
| 0-1 | 36 |
2005 |
FSIM December | A45 Queen's Pawn Game |
| 5. O Nazarenus vs Caruana |
| 0-1 | 38 |
2005 |
FSIM June | A16 English |
| 6. O Katsuhara vs Caruana |
| 0-1 | 41 |
2005 |
FSIM June | A16 English |
| 7. S Paridar vs Caruana |
 | 0-1 | 43 |
2005 |
FSIM June | B22 Sicilian, Alapin |
| 8. Caruana vs T Petrik |
| 0-1 | 43 |
2006 |
Mitropa Cup | C18 French, Winawer |
| 9. A Volodin vs Caruana |
| 0-1 | 50 |
2006 |
4th Young Stars of the World | E14 Queen's Indian |
| 10. F Jenni vs Caruana |
 | 0-1 | 29 |
2006 |
Mitropa Cup | C19 French, Winawer, Advance |
| 11. Caruana vs R Hovhannisyan |
| 0-1 | 35 |
2006 |
4th Young Stars of the World | C42 Petrov Defense |
| 12. A Murariu vs Caruana |
| 0-1 | 40 |
2006 |
FSGM February | C03 French, Tarrasch |
| 13. Caruana vs R Cvek |
| 0-1 | 29 |
2006 |
Mitropa Cup | C18 French, Winawer |
| 14. Caruana vs A Jakab |
| 0-1 | 33 |
2006 |
FSGM February | C19 French, Winawer, Advance |
| 15. Caruana vs J P Le Roux |
| 0-1 | 58 |
2006 |
Mitropa Cup | C54 Giuoco Piano |
| 16. Caruana vs F Bellia |
| 0-1 | 55 |
2006 |
FSGM February | C28 Vienna Game |
| 17. A Muzychuk vs Caruana |
| 0-1 | 59 |
2006 |
FSGM February | C00 French Defense |
| 18. V Onischuk vs Caruana |
 | 0-1 | 29 |
2006 |
4th Young Stars of the World | C18 French, Winawer |
| 19. K Leenhouts vs Caruana |
 | 0-1 | 31 |
2007 |
Hogeschool Zeeland Tournament | B42 Sicilian, Kan |
| 20. S Meenakshi vs Caruana |
 | 0-1 | 27 |
2007 |
5th Gibraltar Chess Festival | A22 English |
| 21. C Vernay vs Caruana |
| 0-1 | 27 |
2007 |
FSGM July | E20 Nimzo-Indian |
| 22. W Stange vs Caruana |
 | 0-1 | 20 |
2007 |
Hogeschool Zeeland Tournament | E44 Nimzo-Indian, Fischer Variation, 5.Ne2 |
| 23. T Fogarasi vs Caruana |
| 0-1 | 23 |
2007 |
FSGM July | B43 Sicilian, Kan, 5.Nc3 |
| 24. J Simpson vs Caruana |
| 0-1 | 37 |
2007 |
5th Gibraltar Chess Festival | A46 Queen's Pawn Game |
| 25. G Antal vs Caruana |
| 0-1 | 59 |
2007 |
First Saturday 4/07 | B43 Sicilian, Kan, 5.Nc3 |